| abstract |
The present invention relates to a shielding membrane in which a peptide having an antimicrobial function that binds to collagen is bound, and more particularly, to a collagen shielding membrane in which a fusion peptide of a collagen binding peptide and an antimicrobial functional peptide is immobilized on a collagen surface. The surface-activated collagen shielding membrane bound to the surface of the fusion peptide of the present invention, when transplanted in vivo, can increase the local retention and stably bind, and promote the migration, proliferation and differentiation of cells involved in bone tissue regeneration. It can be useful for the development of osteoinductive regeneration treatment technology using it can maximize the regeneration power. In addition, the fusion peptide can be applied to other types of grafts made of collagen, and the collagen-binding peptide constituting the fusion peptide can be synthesized by binding to a peptide having regeneration effect in other tissues. Therefore, It can be applied to biomaterials for tissue regeneration. |