| abstract |
Provided herein are vaccine vectors comprising an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Also provided are compositions comprising such vaccine vectors, which include pharmaceutically acceptable carriers, suitably carriers for oral or nasal administration. Also provided is a method for enhancing an immune response, in particular an antibody immune response, preferably an IgA response, by administering a vaccine vector or composition disclosed herein to a subject. |