| abstract |
The present invention relates to a novel library for the production of muteins and to novel muteins derived from human lipocalin 2 (Lcn2, hNGAL) and to related proteins that bind a given target with detectable affinity. will be. The present invention also relates to methods for encoding and producing corresponding nucleic acid molecules such as muteins. For example, it depletes or binds natural biomolecules such as amyloid beta peptides in Alzheimer's disease, such as muteins, or targets fibronectin extra-domainB associated with tumor neovascularization. Do it. |