http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20120115022-A
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ae372ddaa494f2face39592b0429cc16 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-948 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1136 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5308 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-53 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K2-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-10 |
filingDate | 2011-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d40da8461c7dbf5866d9dee7f5b0e282 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50608047928ec4e4faef2f536ca2a7a1 |
publicationDate | 2012-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | KR-20120115022-A |
titleOfInvention | D-Aptide maintains target affinity and improves stability |
abstract | The present invention relates to a structure stabilizing region comprising parallel, antiparallel or parallel and antiparallel D-amino acid strands having interstrand noncovalent bonds formed therein. ); And (b) target binding region I and target binding region II, each of which is bound to both ends of the structure stabilization site and comprises randomly selected n and m D-amino acids, respectively. D-Aptamer-like peptide (D-Aptide) that specifically binds to the target, including the D-Aptide compared to L-Aptide maintains the stability to proteolytic enzymes while maintaining affinity to the target D-Aptide having the same or opposite sequence as L-Aptide characterized by increased. Unlike conventional technical common sense, D-Aptide of the present invention has substantially the same target affinity as compared to L-Aptide, and stability is greatly improved. In addition to its use as a medicament, the D-Aptide of the present invention can be used for the detection of substances in vivo , in vivo molecule imaging, in vitro cell imaging and drug delivery targeting, and as an escort molecule. have. |
priorityDate | 2011-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1120.