abstract |
The present invention provides neutralizing prolactin receptor antibody 006-H08, and its mature forms, and antigen-binding fragments, pharmaceutical compositions containing them, and benign disorders and indications mediated by prolactin receptors, such as endometriosis, uterine adenomyosis, non-hormonal In the treatment or prevention of female contraception, benign breast disease and breast pain, lactation suppression, benign prostatic hyperplasia, fibromatosis, hyper- and normal prolactinemia hair loss, and in co-treatment in combination hormone therapy to inhibit mammary epithelial cell proliferation To its use. Antibodies of the invention block prolactin receptor-mediated signaling. |