| abstract |
The present invention has identified a novel polypeptide, osteoprotegerin binding protein included in osteoclasts, based on the affinity of osteoprotegerin. Also described are nucleic acid sequences encoding polypeptides, or fragments thereof, analogs or derivatives, methods for producing vectors and host cells for protein production, methods for producing and binding of osteoprotegerin binding proteins, bone loss from osteoporosis, arthritis or metastasis, calcium Described herein are compositions and methods for treating hyperemia and bone diseases such as Paget's disease. The receptor, its agonists and antagonists are used to treat bone disease. |