| abstract |
An antigen-binding fragment of a complete human antibody or human antibody that specifically binds to and inhibits human angiopoietin-like protein 4 (hANGPTL) is provided. Human anti-ANGPTL4 antibodies treat diseases or disorders associated with ANGPTL4, such as hyperlipidemia, hyperlipoproteinemia, and dyslipidemia, including hypertriglyceridemia, hypercholesterolemia, kylomicronemia, and the like. Useful for In addition, anti-hANGPTL4 antibodies can be administered to a subject in need thereof to prevent or treat a disease or disorder in which abnormal lipid metabolism is a risk factor. Such diseases or disorders include cardiovascular diseases, such as atherosclerosis and coronary artery disease; Acute pancreatitis; Nonalcoholic fatty liver (NASH); obesity; And the like. |