abstract |
The present invention relates to IL-1β binding proteins including chimeric antibodies, CDR grafted antibodies and humanized antibodies that bind IL-1β. The binding proteins of the invention have a high affinity for IL-1β and neutralize IL-1β activity. The binding protein of the present invention may be a full length antibody or IL-1β binding portion thereof. The present invention also relates to a method of preparing the binding protein of the present invention and a method of using the same. The IL-1β binding protein of the present invention is useful for detecting IL-1β and inhibiting IL-1β activity in human subjects suffering from diseases or disorders in which IL-1β is harmful. |