| abstract |
Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises the deletion of endogenous low affinity FcγR loci and the mouse can express a functional FcRγ-chain. Genetically modified mice comprising mice expressing low-affinity human FcγR genes from the endogenous FcγR locus are described, which mice comprise a functional FcRγ-chain. Genetically modified mice are provided that express up to five low affinity human FcγR genes on accessory cells of the host immune system. |