| abstract |
The present invention relates to compounds of formula (I), which are useful pharmaceutically active compounds. Formula I In Formula I, A, Y, Z, R 20 to R 22 and R 50 have the meanings specified in the claims. Specifically, they are activated by lysophosphatidic acid (LPA) and are inhibitors of endothelial differentiation gene receptor 2 (Edg-2, EDG2), also called LPA 1 receptors, for example atherosclerosis, myocardial infarction And the treatment of diseases such as heart failure. The invention also relates to methods of preparing the compounds of formula (I), their use and pharmaceutical compositions comprising them. |