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filingDate 2010-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12672dc1b93ccd6f647f9f30ae0066e2
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publicationDate 2012-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20120101362-A
titleOfInvention Treatment of water-insoluble nanoparticles with hydrophilic alpha-hydroxyphosphonic acid conjugates, thereby modifying nanoparticles and their use as contrast agents
abstract The present invention relates to water-insoluble nanoparticles, particularly alpha-hydroxy having a hydrophilic moiety that makes nanoparticles of metals and metal compounds useful for diagnostic imaging, such as MR and X-ray imaging, to a sufficient degree of hydrophilicity for use in diagnostic imaging. A method of treating with a phosphonic acid conjugate. Examples of the modified hydrophilic nanoparticles according to the present invention include those in which the hydrophilic moiety of the conjugate used in the modification is an ethylene oxide-based polymer, a copolymer and a zwitterion, and the nanoparticles are superparamagnetic iron oxide and tantalum oxide. It consists of a transition metal oxide such as. The present invention provides nanoparticles having sufficient hydrophilicity to form stable aqueous colloidal suspensions. In addition, diagnostic imaging such as MR and X-rays using the modified hydrophilic nanoparticles as contrast agents is provided.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20150024850-A
priorityDate 2009-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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