http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20120095095-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2b4be2300a741a69aa1b8bb47a88899f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-186 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-24231 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-707 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5767 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-51 |
| filingDate | 2011-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_361d962a0f8878ec71f4576c056be842 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2df335f7df7e8ebe80dba084631a2264 |
| publicationDate | 2012-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20120095095-A |
| titleOfInvention | Interferon alpha-resistant hepatitis C virus |
| abstract | Interferon in JFH-1 infected cell line Huh7.5 to establish a clone that is resistant to interferon alpha in hepatitis C virus (HCV) to investigate the molecular cause of failure of treatment of chronic hepatitis C patients with interferon alpha. After long periods of alpha treatment at low concentrations, clones surviving the interferon alpha treatment concentration of 100 U / ml were selected. Genetic analysis of this clone confirmed that the mutation occurred by replacing four C-terminal coding sequences of non-structural gene 5A (NS5A). And by injecting these four mutations into wild-type JFH-1, a new HCV clone that is resistant to interferon alpha could be produced. These results indicate that the amino acid sequence changes of four NS5A proteins are involved in interferon alpha resistance, and the newly established resistant clones serve as a tool to explain the interferon alpha resistance mechanism of HCV patients. |
| priorityDate | 2011-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 290.