| abstract |
The present invention generally relates to the field of therapeutic compounds. More specifically, the present invention provides certain (4-phenyl-piperidin-1-yl)-[5- (1H-pyrazole-) that specifically inhibits 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). 4-yl) -thiophen-3-yl] -methanone compound. The present invention also provides pharmaceutical compositions containing such compounds, and in vitro and in vivo, diseases which inhibit 11β-hydroxysteroid dehydrogenase type 1 and are ameliorated by inhibition of 11β-hydroxysteroid dehydrogenase type 1 Treat metabolic syndrome, including diseases such as type 2 diabetes and obesity, and related diseases including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischemic (coronary) heart disease, mild cognitive impairment and It relates to the use of such compounds and compositions for treating CNS diseases such as early dementia, such as Alzheimer's disease. |