| abstract |
The present invention relates to 2'-fluoro-6'-methylene carbocyclic nucleosides, pharmaceutical compositions containing said nucleosides, and in particular to drug resistance of the following viruses [particularly lamivudine and / or adefovir ( hepatitis B virus (HBV) and its secondary disease states and diseases (cirrhosis and liver cancer), hepatitis C virus (HCV), herpes simplex viruses I and II, including adefovir) (HSV-1 and HSV-2), cytomegalovirus (CMV), varicella zoster virus (VZV) and Epstein bar virus (EBV), and many of its secondary cancers (lymphoma, nasopharyngeal cancer) The use of the above for use in the treatment or prevention of viral infections and their secondary disease states and diseases. |