abstract |
The present invention provides compounds for use in pharmaceutical compositions and methods for modulating the activity of nuclear receptors. In particular, there is provided a compound for use in compositions and methods for modulating the Farnesoid X receptor, ie a compound of formula (I) or a pharmaceutically acceptable derivative thereof: In this formula, R 1 is —C (J) OR 14 , —C (J) SR 14 or —C (J) N (R 15 ) R 16 ; J is O, S or NR 17 ; R 2 is hydrogen, halo or substituted or unsubstituted alkyl; R 3 is —C (O) R 9 ; R 4 , R 5 , R 6 and R 7 are as described in the claims. |