abstract |
Anticaine antibodies bind to two, three, four, five or more CC chemokines such as RANTES / CCL5, MIP-1α / CCL3, MIP-1β / CCL4 or MCP-1 / CCL2. Also disclosed are methods of humanization and affinity maturation of anticaine antibodies as well as generation of hybridoma cell lines that produce anticaine antibodies by sequential immunization. |