| abstract |
The present invention relates to purified antibody molecules, The at least one antigen binding site comprises glycosylated asparagine (Asn) at the variable region of the heavy chain (V H ), and more particularly pharmaceutical and diagnostic compositions comprising the antibody molecule and antibody mixtures comprise β-A4 peptide / Aβ4. Provided specifically for recognition, the invention particularly relates to antibody mixtures comprising one or two glycosylated antigen binding sites with glycosylated asparagine (Asn) in the variable region of the heavy chain, ie the heavy chain (V H ). To antibody preparations or compositions comprising a mixture of antibody isomers comprising glycosylated Asn at variable sites, and also specific glycosylated antibody isomers, and further to pharmaceutical and diagnostic uses for such antibodies, Isomers can be used, for example, for pharmaceutical prophylaxis and / or diagnosis of amyloid production or amyloid-plaque formation. The. |