| abstract |
The present invention relates to compounds of formula (I): The present invention relates to compounds which inhibit, modulate and / or modulate PI3K and / or mTOR, which are useful for the treatment of hyperproliferative diseases such as cancer in mammals. To provide. The present invention also provides methods of preparing the compounds, methods of using such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and pharmaceutical compositions containing such compounds. For example, cancers in which activity against PI3K-alpha, mTOR, or both contribute to pathology and / or symptomatology include breast cancer, mantle cell lymphoma, renal cell carcinoma, acute myeloid leukemia, chronic myeloid leukemia, NPM / ALK Metamorphic anaplastic large cell lymphoma, diffuse large B cell lymphoma, rhabdomyosarcoma, ovarian cancer, endometrial cancer, cervical cancer, non-small cell lung carcinoma, small cell lung carcinoma, adenocarcinoma, colon cancer, rectal cancer, gastric carcinoma, hepatocellular carcinoma, melanoma There are pancreatic cancer, prostate carcinoma, thyroid carcinoma, anaplastic large cell lymphoma, hemangioma, glioblastoma, or head and neck cancer: . |