| abstract |
The present invention relates to a lung injury model animal due to peroxygen exposure, and a kit for diagnosing lung injury by peroxygen exposure using a TAZ marker, wherein (TAZ -/- ) mice lacking TAZ genes induce severe pulmonary fibrosis symptoms. were, which as was similar to the pulmonary fibrosis induced in mice with oxygen-exposed control group lungs, TAZ is by inhibiting the signaling molecules act on the relevant signal path oxidative stress, since the function in homeostasis of the lung, the TAZ - / - Mice can be usefully used as pulmonary fibrosis model mice by exposure to peroxygen, as well as the production of pulmonary fibrosis model mice by exposure to peroxygen, and useful for screening therapeutic candidates using the TAZ gene or By confirming the expression of the protein, it can be usefully used for the diagnosis and diagnosis kit for pulmonary fibrosis due to peroxygen exposure. |