| abstract |
The present invention relates to the compounds of formula I, its stereoisomers, geometric isomers, tautomers and pharmaceutically acceptable salts of benzoxazepine compounds, which have anticancer activity and more specifically inhibit PIK3 kinase activity: (I) In this formula, Z 1 is CR 1 or N; Z 2 is CR 2 or N; Z 3 is CR 3 or N; Z 4 is CR 4 or N; B is a pyrazolyl, imidazolyl or triazolyl ring. |