| abstract |
The present invention relates to a compound of formula (I) or a pharmaceutically active salt, racemic mixture, enantiomer, optical isomer or tautomer thereof: Formula I Where R 1 is hydrogen or lower alkyl; R 2 is hydrogen, lower alkyl, halogen-substituted lower alkyl, halogen or CN, which may be independent of each other if o is 2; Ar 1 is aryl or heteroaryl; Ar 2 is aryl or heteroaryl; R 'and R "are independently of each other hydrogen, lower alkyl, lower alkoxy, halogen, C (O) -lower alkyl, cyano or halogen-substituted lower alkyl; when n is 0, m is 0, 1, or 2; when n is 1, m is 0 or 1; n is 0 or 1; o is 1 or 2; The compounds of the present invention have been found to be high potential NK-3 receptor antagonists for treating depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit disorder (ADHD). |