| abstract |
The present invention relates to cyclic indolizincarboxamides and azaindoligincarboxamides of formulas Ia and Ib, which are useful pharmaceutically active compounds. Ia (Ib) In the above formulas Ia and Ib, R, R a , R 10 , R 20 , R 30 , R 40 , Y, n, p and q are as defined in the claims. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system and are useful for the treatment of diseases such as, for example, hypertension. The invention further relates to a process for the preparation of the compounds of formulas (la) and (lb), their use and pharmaceutical compositions comprising the same. |