| abstract |
The present invention relates to tetra-substituted heteroaryl compounds of formula (I) <Formula I> Wherein X 1 , X 3 and X 4 are independently C or N and Y is CH, NH or N, where the total number of nitrogen atoms represented by X 1 , X 3 , X 4 and Y is 1 or 2; Rings A and B are independently selected from phenyl or pyridyl; R 1 , R 4 , R ', R ", n and m are as defined herein. Such compounds are suitable for the treatment of disorders or diseases mediated by the activity of MDM2 and / or MDM4 or variants thereof. |