http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20120046070-A

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assignee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_430c89d97f6839f5364904e710af9704
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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11
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filingDate 2011-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a311efd9ec9ef765e5cdf1da0193a15e
publicationDate 2012-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20120046070-A
titleOfInvention EFRF Exon 21 LJ5JR primer for detecting polymorphism and use thereof
abstract The present invention provides a set of primers for polymorphism detection for detecting the genetic variation of EGFR exon 21 L858R. The primer set has a P1 oligonucleotide and a P2 oligonucleotide, and can be amplified using a region containing the 172792th base of the nucleotide sequence shown in SEQ ID NO: 1 as a template. As a base complementing the 172792th base of the nucleotide sequence shown in SEQ ID NO: 1, the P1 oligonucleotide has C and the P2 oligonucleotide has A. The P1 oligonucleotide exhibits a high Tm value compared to the Tm value of the P2 oligonucleotide, and / or the P1 oligonucleotide is one base longer than the P2 oligonucleotide. The present invention also provides a primer for detecting a polymorphism, a polymorphism detection method using the primer set, an evaluation method of an EGFR tyrosine kinase inhibitor using the primer set, a primer used in the polymorphism detection method, and a kit comprising the primer set. To provide.
priorityDate 2010-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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