| abstract |
The present invention relates to a compound that inhibits HIF-1 activity, a preparation method thereof, and a pharmaceutical composition containing the same as an active ingredient. The compound according to the present invention exhibits anticancer activity by inhibiting the activity of HIF-1, a transcription factor that plays an important role in the growth and metastasis of cancer cells, rather than by antiselective cytotoxicity. Therefore, the compound according to the present invention or a pharmaceutically acceptable salt thereof may be used as a therapeutic agent for various solid cancer diseases such as colorectal cancer, liver cancer, gastric cancer and breast cancer by inhibiting HIF-1 activity. In addition, the compound or a pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient of a therapeutic agent for diabetic retinopathy or arthritis which is exacerbated by an increase in the expression of VEGF by HIF-1 in a hypoxic state. |