| abstract |
The present invention relates to a composition for preventing and treating asthma containing cystatin C as an active ingredient, specifically, mass-producing cystatin C derived from humans and mice and egg whitening the produced cystatin C. Direct injection into albumin-sensitized asthma-induced animal models has shown effects such as suppressing airway hypersensitivity, decreasing eosinophils and inflammatory cells in bronchoalveolar lavage fluid, decreasing inflammatory mediators in bronchoalveolar lavage fluid, and inhibiting inflammatory cell infiltration in airway mucosa. Since it has been confirmed, the cystatin C protein of the present invention can be usefully used for the composition for the prevention and treatment of asthma, as well as can be useful for the method of screening for asthma diagnosis or asthma therapeutic agent using the same. |