http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20120036506-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_046b94174ff188b5b5d0c4605583ee11 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1029 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0623 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y203-01006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0797 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| filingDate | 2010-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b3a21769346bfa77a823b472a826caf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f834b22e546f69c715cb6cbf03e8f5c5 |
| publicationDate | 2012-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20120036506-A |
| titleOfInvention | Human neural stem cells expressing human choline acetyltransferase and use thereof |
| abstract | The present invention is transformed into a vector comprising a human choline acetyltransferase (ChAT) coding nucleotide sequence, human neural stem cells expressing ChAT enzyme, pharmaceutical compositions for treating Alzheimer's disease comprising the same, and learning or memory capacity It relates to a composition for improving cognitive impairment such as. Human neural stem cells genetically modified to express human ChAT, when transplanted into the brain of an Alzheimer's disease animal model, were successfully bound to the host's brain tissue and differentiated into normal neurons, and stably expressed ChAT, resulting in the reduction of acetylcholine. The concentration was restored to normal level. It also improved the cognitive function of Alzheimer's animal models with impaired cognitive function. Therefore, the ChAT-expressing human neural stem cells of the present invention can be developed as a medicament for the treatment of Alzheimer's disease and the improvement of cognitive impairment such as learning ability or memory ability caused by the disease. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101445312-B1 |
| priorityDate | 2010-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 558.