abstract |
The present invention relates to new high-permeability compositions (HPC) or high-permeability prodrugs (HPP) of antimicrobial agents and antimicrobial-related compounds that can cross the biological barrier with high permeability efficacy. HPC / HPP can be converted to a parent active drug or drug metabolite after crossing the bio-barrier to treat conditions that can be treated with the parent drug or metabolite. In addition, HPP allows new treatments by allowing its parent drug to reach a site that is inaccessible or at a sufficient concentration. HPPs can be administered to a subject through various routes of administration, for example, can be delivered locally at high concentrations to the site of pathological action or can be systemically administered to a biological subject and introduced into the large circulation at a rapid rate. |