| abstract |
Apoptosis-induced solid dispersions are Bcl-2 family protein inhibitor compounds, eg, dispersed in a solid matrix comprising (a) a pharmaceutically acceptable water soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. And ABT-263 in an essentially amorphous form. A method for producing such a solid dispersion is a solid matrix comprising the polymeric carrier and the surfactant by dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent and removing the solvent, wherein the solid matrix Providing a solid matrix comprising the compound dispersed in an essentially amorphous form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treating a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 lineage proteins, eg cancer. |