| abstract |
The present invention provides novel substituted 8-sulfonyl-2 of general formula (1) which simultaneously shows physiological activity against alpha-adrenergic receptor, dopamine receptor, histamine receptor, imidazoline receptor, sigma receptor, norepinephrine receptor, serotonin receptor. 3,4,5-tetrahydro-1 H -γ-carboline and pharmaceutically acceptable salts thereof-Pharmaceutical compositions comprising novel ligands as ligands, active ingredients, active ingredients, conditions and diseases of the central nervous system It relates to a new drug for the treatment of. In general formula 1 R 1 is a substituent selected from hydrogen, optionally substituted C 1 -C 3 alkyl or C 1 -C 4 alkyloxycarbonyl; R 2 is a ring-based substituent selected from hydrogen, optionally substituted C 1 -C 3 alkyl, optionally substituted C 2 -C 3 alkenyl or substituted sulfonyl; R 3 represents an optionally substituted aryl or substituted amino group. |