| abstract |
The present invention relates to a pharmaceutical composition for the prevention or treatment of immune diseases and inflammatory diseases, including stem cells cultured by adding agonists of NOD2 to the stem cells expressing NOD2, or a culture thereof, and more particularly, the pharmaceutical composition. A method of inhibiting an immune or inflammatory response in a subject comprising administering a composition, said stem cell or culture thereof to a subject, a method of producing an immunosuppressant or anti-inflammatory agent using said stem cell or culture thereof , PGE 2 comprising the step of culturing by adding agonists of NOD2 to stem cells expressing NOD2 Or a method for producing TGF-β1, a transplant comprising a stem cell expressing NOD2 and an agonist of NOD2, a method for preparing the transplant, a complex comprising a stem cell expressing NOD2 and an agonist of NOD2 and NOD2 It relates to a culture obtained by adding an agonist of NOD2 to expressing stem cells. The pharmaceutical composition according to the present invention is a cell therapy that can be used economically without side effects and replaces existing immunosuppressive agents and inflammatory inhibitors with known side effects, such as autoimmune diseases such as Clones disease, rheumatoid arthritis, atopy, and infections and It can be used to prevent or treat inflammatory diseases. |