abstract |
Methods of screening for compounds that inhibit neurodegeneration are provided. Shading of APP may be a useful marker for neurodegeneration, and compounds that inhibit shedding of APP are useful as inhibitors of neurodegeneration. Such compounds may be useful for the treatment and / or prevention of various neurological diseases, disorders and neuronal damage and may enhance the growth, regeneration or survival of mammalian neuronal cells or tissues. |