abstract |
The present invention relates to a novel sustained glucagon conjugate covalently linked to a polymer carrier by a non-peptide linker and a pharmaceutical composition for preventing and treating obesity comprising the same as an active ingredient. The sustained glucagon conjugate according to the present invention is improved in vivo sustainability and stability, significantly reducing the dose when co-administered with anti-obesity drugs while showing improved medication compliance without fluctuations in blood glucose, thereby preventing and treating obesity. It can be very useful. |