| abstract |
The present invention relates to tumor treatment. In one aspect, the invention relates to a conjugate of target binding sites and toxins useful for the treatment of cancer. In particular, the toxin is amatoxin and the target binding site (eg, antibody) is directed to a tumor associated antigen such as epithelial cell adhesion molecule (EpCAM). In a further aspect, the present invention relates to pharmaceutical compositions comprising such target-binding site toxin complexes and to the use of said target binding site toxin complexes for the preparation of such pharmaceutical compositions. Target binding site toxin complexes and pharmaceutical compositions of the invention are useful for the treatment of cancer, in particular adenocarcinoma, such as pancreatic cancer, bile duct cancer, breast cancer and colon cancer. |