http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20110129045-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d932caef0dfe635678936c767a7537de |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4436 |
| filingDate | 2010-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc7501937ea16b762ee3c7a36d3e4204 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6c584943d25374a9fdb065735564dfc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35d927ff3e710c3cecf026ac398ce273 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d0aa3a973ffc6818be71a96053417de |
| publicationDate | 2011-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20110129045-A |
| titleOfInvention | Process for preparing pioglitazone hydrochloride using cyclic amine intermediate |
| abstract | The present invention relates to a method for the preparation of pioglitazone hydrochloride represented by the formula (1) as a therapeutic and prophylactic agent for diabetes with hypoglycemic and hypoglycemic activity, and more particularly to the preparation of the intermediate represented by the formula (4) The compound represented by the formula (6) was prepared by a mating reaction with the compound represented by the formula (5), and the intermediate was reacted with the formula (9) after the reduction reaction to prepare the pioglitazone represented by the formula (2), followed by thiazoli The present invention relates to a method for efficiently preparing pioglitazone hydrochloride while removing a protecting group of din-2,4-dione in the presence of hydrochloric acid. In the following formulae, Z represents a protecting group, and preferably t-butyloxycarbonyl group (t-BuOC = O) and trityl group (Trityl, -C (Ph) 3) . <Formula 1> <Formula 2> <Formula 4> <Formula 5> <Formula 6> ≪ Formula 9 > |
| priorityDate | 2010-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 133.