http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20110124941-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e5351c62aee4203f2be2944f21a6def2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-513 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4965 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 |
| filingDate | 2010-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1de2f7b56acb26d46ccbf870339ad53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce33388d523826a1d83968903231d13d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b43eb27a2d493d5cff99b10d1676433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ad3759904e904f362593f2d13251d4d |
| publicationDate | 2011-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20110124941-A |
| titleOfInvention | Use of TB1, MB1, AT1 or RA1 for the treatment of fungal infections |
| abstract | The present invention is the use of an inhibitor against a protein or gene of Tco1, Mbp1, Atf1 or Ras1 of Cryptococcus neoformans for the preparation of an antifungal agent, an antifungal pharmaceutical composition comprising the inhibitor, an effective amount of the inhibitor Provided is a method for treating a fungal infection comprising administering to a subject. In the present invention, the hypersensitivity of the genes in the HOG pathway of Cryptococcus neoforms to the known antifungal agent is investigated. It is newly found to increase. Inhibition of the Tco1, Mbp1, Atf1 or Ras1 genes can significantly increase the efficacy of nucleic acid synthesis inhibitory antifungal agents, such as Tco1, Mbp1, Atf1 or Ras1 of Cryptococcus neoforms. An antifungal pharmaceutical composition comprising an inhibitor against a gene or a protein encoded by the same can be used as an excellent complex antimicrobial therapeutic agent that can increase the efficacy while reducing the use amount of a nucleic acid synthesis inhibitory antifungal agent. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016159653-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20160097751-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20210069015-A |
| priorityDate | 2010-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 794.