| abstract |
The present invention provides a) Bmi1 (B cell-specific Moloney murine leukemia virus integration site 1) protein or a nucleic acid molecule encoding Bmi1 protein; And b) a composition which induces the differentiation of embryonic stem cell-like cells from somatic cells comprising a G9aHMTase inhibitor and a DMNT inhibitor, and a method for producing embryonic stem cell-like cells using the same. According to the present invention, in addition to four genes (Oct4, Sox2, Klf4, and C-Myc / Oct4, Sox2, Nanog, Lin28), which are the main factors for inducing differentiation, only one new Bmi1 gene is introduced and a low molecular weight chemical By treating the G9aHMTase inhibitor and the DMNT inhibitor, there is an advantage of providing embryonic stem cell-like cells having pluripotency while minimizing the number of dedifferentiation inducing factors in a relatively simple manner. |