| abstract |
The present invention relates to a peptide or peptide derivative having the formula: Wherein X 1 is a nonpolar hydrophobic group or a positively charged group, D 2 is an asparagine or glutamine, K 3 , X 2 and X 4 are positively charged groups, X 3 is a positively charged group, proline Or a proline derivative, L 7 and I 16 are nonpolar hydrophobic groups, Y 6 and Y 17 are tyrosine, R 9 and R 14 are arginine, N 18 and N 19 are asparagine or glutamine, P 4 , P 5 , P 8 , P 10 , P 12 , P 13 and P 17 are proline, hydroxyproline or derivatives thereof, where possible D 2 , P 4 , P 5 , P 8 , P 10 , P 12 , P One or two of the groups selected from 13 , P 17 and Y 17 are replaced with any group and / or P 13 and R 14 are exchanged, Sub 1 is free or modified N-terminus and Sub 2 is free or Modified C-terminus. The invention also relates to the use of peptides and peptide derivatives in medicine, as antibiotics, in fungicides or detergents, as preservatives or in packaging materials, in pharmaceutical research, or in screening methods. |