| abstract |
The present invention relates to a pharmaceutical composition for treating atherosclerosis containing melittin, which is an active ingredient of bee venom that can reduce the expression level of atherosclerotic hardening factor and inflammatory factor and vascular adhesion factor. The administration of chitin to arteriosclerosis models reduced total cholesterol and triglycerides and maintained or increased high-density cholesterol, and decreased the levels of inflammatory cytokines TNF-α and IL-1β in the blood. , Decreased expression of fibrin-related cytokines and angiogenesis factors in the aorta and heart, decreased plaque deposition commonly found in atherosclerosis, expression of ICAMs and VCAMs, fibrotic cytokines TGF-β1 and fibronectin, at the protein level It has the effect of reducing the amount. |