http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20110116356-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c28c73bfedd33194136c0cfb45a6b0df |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-503 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4406 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-02 |
| filingDate | 2010-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67abeb0a244a8bae3f9181d890116732 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1b4c49aafe69a5300b76514dc56b7e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_766c7bc413a7fea96398e12d2320a472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_830e7b95063f3e53b850c6cff279c1a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b8ece2dd3eaf7aed4d74567ad3af83d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff5cdf318d0964f7c57e7640351c7537 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f30078e17b7d75ff099af2481575556c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95e84b14d7868754827578184faf5edf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e253748191d7c529caf390e6b4439e79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6661696e805e2ea678bfe5469d437cb7 |
| publicationDate | 2011-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20110116356-A |
| titleOfInvention | 3-amino-2,6-dichloropyridine derivative having a function of increasing the activity of RUBN2, and a composition for promoting bone formation containing the same |
| abstract | The present invention relates to a 3-amino-2,6-dichloropyridine derivative having an action of increasing the activity of Runx2, and more particularly, the activity of Runx2, a transcription factor necessary for bone formation in osteoblasts responsible for bone formation. It relates to a 3-amino-2,6-dichloropyridine derivative represented by the following formula (1) or a pharmaceutically acceptable salt thereof having excellent activity of promoting bone formation by increasing the concentration thereof and the use thereof. The 3-amino-2,6-dichloropyridine derivative represented by Formula 1 according to the present invention is effective in stimulating bone formation by increasing the activity of Runx2, which is a transcription factor necessary for bone formation, to induce bone formation. Since it is less, it can be usefully used for the prevention and treatment of bone diseases such as osteoporosis, fracture, bone graft, periodontal disease, and bone insufficiency. [Formula 1] In Chemical Formula 1, R 1 is a C 3 -C 6 heterocyclic ring, a -NR 2 R 3 group, , In the substituents representing R 1 , R 2 and R 3 each represent hydrogen, a C 1 -C 6 straight chain or crushed alkyl group,-(CH 2 ) n -R 6 , and R 4 is hydrogen, C 1 -C 4 linear or pulverized alkyl group,-(CH 2 ) n -R 7 represents, R 5 is hydrogen, C 1 -C 4 linear or pulverized alkyl group, hydroxy group, halogen, carbamoyl group, acetamido group , C 3 -C 6 heterocyclic ring. In the substituents represented by R 2 and R 3 , R 6 is a hydroxy group, a halogen, a cyano group, a C 3 -C 6 cyclic alkyl group, a carbamoyl group, an acetamido group, a C 1 -C 4 straight chain or pulverized A phase alkoxy group, a C 1 -C 4 straight or pulverized alkylthio group, a C 2 -C 6 straight or pulverized dialkylamino group, a C 3 -C 6 heterocyclic ring, In the substituent representing R 4 , R 7 represents a hydroxy group, a C 1 -C 4 linear alkoxy group, a C 1 -C 4 alkylcarbamoyl group, a C 3 -C 6 heterocyclic ring, Indicates. In the substituent representing R 6 , R 8 represents a hydrogen, a halogen, a hydroxyl group, a C 1 -C 4 linear alkyl group, a C 1 -C 4 linear alkoxy group, a trifluoromethyl group, and a substituent representing R 7 . R 9 represents hydrogen, a halogen, a hydroxyl group, a C 1 -C 4 linear alkyl group, a C 1 -C 4 linear alkoxy group, a cyano group, an acetyl group, a trifluoromethyl group, and a nitro group, and n is 0 The integer of -6 is shown. |
| priorityDate | 2010-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 311.