| abstract |
The present invention provides novel compounds that inhibit cell proliferation and cell differentiation and inhibit the activation of ischemic factor (HIF) -mediated transcription and signaling under ischemic conditions. In one embodiment, the compounds of the present invention are useful for the preparation of a medicament for the treatment or prevention of a disease or disorder selected from the group consisting of inflammatory diseases, hyperproliferative diseases or disorders, ischemia-related diseases and diseases indicative of excessive angiogenesis. Do. The present invention also provides a pharmaceutical composition comprising the compound of the present invention and a second therapeutic agent or radiation, which is useful for the treatment or prevention of the abovementioned diseases or conditions. As a first aspect, the present invention relates to a compound having a structure according to general formula (I). |