| abstract |
The present invention relates to compounds of formula (I) in base form or in acid addition salt form, as well as methods of making and treating the compounds. <Formula I> Where n is 0, 1, 2, 3 or 4; m is 0, 1 or 2; o is 0 or 1; X is -CH 2 , -CH (R ')-, -NH (R')-, or a heteroatom selected from O and S; R 'is-(C1-C5) alkyl,-(C1-C5) alkoxy, -CH 2 -aryl, -C (O) R5 or -COOR5; R1 is oxo, -COOR5, -W-OH or -W-NR5R6; R 2 is H atom or (i)-(C 1 -C 5) alkyl, (ii)-(C 1 -C 5) alkoxy, (iii) -COOR 5, (iv) -NR 5 R 6, (v) -C (O) -NR 5 R 6 , (vi) -SO 2 -NR 3 R 4, (vii) heteroaryl optionally substituted with-(C 1 -C 5) alkyl, (viii) -W-aryl, (ix) -W-heteroaryl, (x) -OW- Aryl, (xi) -OW-heteroaryl and (xii) -OW-NR5R6; R3 and R4 may be the same or different, (i) independently of one another H atoms,-(C 1 -C 5) alkyl,-(C 3 -C 6) cycloalkyl, aryl, heteroaryl, -CH 2 -heteroaryl,-(C 1 -C 5) alkyl-NR 5 R 6, -W -OH or -W-NR5R6; or (ii) together with the nitrogen atom bearing them, form a heterocycloalkyl group optionally substituted with one or more groups selected from-(C1-C5) alkyl and -CH 2 -aryl groups; W represents a-(C 1 -C 5) alkylene group optionally substituted with one or more hydroxyl groups; R5 and R6, which may be the same or different, are independently of each other a hydrogen atom, or a group selected from-(C1-C5) alkyl group and-(C3-C6) cycloalkyl group. |