Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_82ae8798cdec6cc8f8ad3eb62813831e |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-322 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-344 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-141 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-342 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-52 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1131 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 |
filingDate |
2009-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c39b20a213980a1a61faf68092003dad |
publicationDate |
2011-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
KR-20110110776-A |
titleOfInvention |
Extended Dicer Substrate Formulations and Methods for Specific Inhibition of Gene Expression |
abstract |
The present invention provides compositions and methods for reducing the expression of a target gene in a cell, comprising contacting the cell with an isolated double stranded nucleic acid (dsNA) in an effective amount to reduce the expression of the target gene in a cell. The dsNA of the present invention has a deoxyribonucleotide pattern designed to indicate a dicer enzyme cleavage site in the dsNA molecule (in most embodiments, the pattern comprises one or more deoxyribonucleotide-deoxyribonucleotide base pairs). . The deoxyribonucleotides of the dsNA molecules of the invention are cleaved through the cleavage site to produce an active siRNA preparation that no longer contains a deoxyribonucleotide pattern (eg, deoxyribonucleotide-deoxyribonucleotide base pairs). Located within the dsNA region. The DNA extended dicer substrate siRNA (DsiRNA) has proven to be an effective RNA inhibitor than the corresponding double stranded RNA-extended DsiRNA. DsiRNA preparations have also been found to be tolerant of guide strand mismatch. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016006846-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102379204-B1 |
priorityDate |
2008-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |