| abstract |
The present invention relates to a method for selecting, isolating and / or recovering a peptide or polypeptide that is resistant to degradation by a protease, such as a protease found in serum, from a library or repertoire of peptides and polypeptides (eg, a display system). It is about. Generally, such methods include providing a library or repertoire of peptides or polypeptides, incubating the library or repertoire with a protease under conditions appropriate for protease activity, and resistant to degradation by the protease and having a desired biological activity. Selecting, isolating and / or recovering the peptide or polypeptide. Selected peptides and polypeptides are useful as therapeutic agents, for example in treating diseases in humans. |