Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6c69e07081c3ffc6e6c7678c48812a09 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7105 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105 |
filingDate |
2010-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3886eb15292cb5cf1a4c08b252d116bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83771c0f5cd89c04c34b5ccf990f8913 |
publicationDate |
2011-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
KR-20110081715-A |
titleOfInvention |
SiRNA, which reduces gene expression specifically for HIF-1α in osteoclasts |
abstract |
The present invention has a nucleotide sequence of SEQ ID NO: 1 and 2 and siRNA (small interfering RNA) to reduce the gene expression specifically to hypoxia-inducible factor-1 alpha (HIF-1α) in osteoclasts (osteoclast) ). The siRNA of the present invention inhibits the expression of HIF-1α caused by hypoxia and inhibits the activity of osteoclasts, thereby inhibiting osteoclast differentiation and activation such as osteoporosis, degenerative arthritis, rheumatoid arthritis, bone destruction caused by cancer, or metabolic bone disease. It can prevent or treat a disease or a disease caused by it. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2014104406-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014104406-A1 |
priorityDate |
2010-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |