| abstract |
Enhances and / or prolongs the activation of T cells (ie, increases antigen-specific proliferation of T cells, enhances cytokine production by T cells, and / or differentiates and effector functions of T cells And / or promote T cell survival), and overcome T cell depletion and / or energy. Suitable compositions include PD-1, which binds and blocks the endogenous PD-1 receptor without triggering an inhibitory signal from PD-1, or binds and blocks the PD-1 receptor ligand to prevent them from interacting with the PD-1 receptor. Receptor antagonists. Provided are methods of using PD-1 receptor antagonists to enhance an immune response in a subject in need thereof. |