| abstract |
The present invention provides a fusion protein comprising a signal peptide, an EGF repeat 1-X (where X is any integer from 12 to 34) of the extracellular domain of a human Notch3 receptor protein and an Fc portion of an antibody bound thereto. . The invention also provides a method of treating a subject with cancer, a method of inhibiting angiogenesis in a subject, a subject having ovarian cancer, comprising administering to the subject an amount of the fusion protein effective to treat the subject. Methods of treating and treating subjects with metabolic disorders are provided. The present invention provides for the manufacture of a pharmaceutical composition used for the treatment of a subject with a tumor, to inhibit angiogenesis in the subject, to treat a subject with ovarian cancer, and to treat a subject with metabolic disorders. Further provided is the use of said fusion protein. |