| abstract |
It is an object of the present invention to diagnose the predisposition to which pancreatic and prostate cancers, in particular pancreatic ductal adenocarcinoma (PDAC) and castration-resistant prostate cancer, occur. In one embodiment, the diagnostic method comprises determining the expression level of C12ORF48 using siRNA targeting the C12ORF48 gene. The invention also features a substance such as siRNA and a composition comprising the same. The present invention provides methods for inhibiting cell growth and methods for treating or alleviating one or more disease symptoms, as well as methods for screening therapeutic agents useful for the treatment of cancer, eg, C12ORF48 related diseases such as pancreatic cancer and prostate cancer. Provide more. It also features materials such as vectors and compositions comprising them, as well as double-stranded molecules. |