| abstract |
The present invention relates to a process for the preparation of lufinamide of formula (I), wherein the process comprises (i) 2,6-difluorobenzylhalide of formula (II), wherein X is chlorine, bromine, or Iodine) to react with azide to obtain 2- (azidomethyl) -1,3-difluorobenzene of formula (III); (ii) methyl 1- (2,6-difluorobenzyl) of formula (IV) by reacting 2- (azidomethyl) -1,3-difluorobenzene of formula (III) with methyl propiolate Obtaining -1H-1,2,3-triazole-4-carboxylic acid; And (iii) a rupee of formula (I) by reacting methyl 1- (2,6-difluorobenzyl) -1H-1,2,3-triazole-4-carboxylic acid of formula (IV) with ammonia Obtaining amide. |