| abstract |
The present invention provides compositions and methods for controlling intracellular osmolarity in cells, including cultured cells, including, for example, cultured cells in bioreactors. The present invention provides nucleic acids comprising at least one osmo-reactive transcriptional regulatory element (OR-TRE), and cells, vectors, articles of manufacture, artificial organs or implants, etc. containing an osmo-reactive transcriptional regulatory element (OR-TRE). do. |